Expressive

rs117737118 - GRM8

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of type 2 diabetes loci in 433,540 East Asian individuals - Unknown journal (n.d.) · Unknown authors · PubMed 32499647

    ABSTRACT: SUMMARY Meta-analyses of genome-wide association studies (GWAS) have identified >240 loci associated with type 2 diabetes (T2D), however most loci have been identified in analyses of European-ancestry individuals. To examine T2D risk in East Asian individuals, we meta-analyzed GWAS data in 77,418 cases and 356,122 controls. In the main analysis, we identified 301 distinct association signals at 183 loci, and across T2D association models with and without consideration of body mass index and sex, we identified 61 loci newly implicated in T2D predisposition. Common variants associated with T2D in both East Asian and European populations exhibited strongly correlated effect sizes. New associations include signals in/near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • low glycemic load dietary pattern Moderate

    Reduces postprandial glucose spikes and improves insulin sensitivity

    Prioritize whole grains, legumes, non-starchy vegetables; limit refined carbohydrates

Exercise

  • regular aerobic and resistance exercise Moderate

    Physical activity reduces insulin resistance and improves glucose metabolism

    150 minutes moderate-intensity aerobic activity weekly, 2x weekly resistance training

Lifestyle

  • weight management if overweight Moderate

    Excess weight increases insulin resistance; modest weight loss improves glucose control

    Target BMI 18.5-24.9, or 0.5-1 lb per week loss if overweight

Screening

  • fasting glucose and HbA1c screening Moderate

    Early detection of glucose dysregulation enables timely intervention

    Baseline screening, then every 1-3 years or per clinical guidelines