rs117732931 - NRXN3

Magnitude 2.0 · 1 study on file

Reported associations

• Identification of Pancreatic Cancer Germline Risk Variants With Effects That Are Modified by Smoking. - JCO precision oncology (2024) · Zhu H, Choi J, Kui N, Yang T, Wei P, Li D, Sun R · PubMed 38564682

  Pancreatic cancer (PC) is a deadly disease most often diagnosed in late stages. Identification of high-risk subjects could both contribute to preventative measures and help diagnose the disease at earlier timepoints. However, known risk factors, assessed independently, are currently insufficient for accurately stratifying patients. We use large-scale data from the UK Biobank (UKB) to identify genetic variant-smoking interaction effects and show their importance in risk assessment. We draw data from 15,086,830 genetic variants and 315,512 individuals in the UKB. There are 765 cases of PC. Crucially, robust resampling corrections are used to overcome well-known challenges in hypothesis testing for interactions. Replication analysis is conducted in two independent cohorts totaling 793 cases a

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