rs117724125 - NR5A1
Magnitude 4.5 · 1 study on file
Reported associations
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Two genetic loci associated with ankle injury - Unknown journal (n.d.) · Unknown authors · PubMed 28957384
ABSTRACT: Ankle injuries, including sprains, strains and other joint derangements and instability, are common, especially for athletes involved in indoor court or jumping sports. Identifying genetic loci associated with these ankle injuries could shed light on their etiologies. A genome-wide association screen was performed using publicly available data from the Research Program in Genes, Environment and Health (RPGEH) including 1,694 cases of ankle injury and 97,646 controls. An indel (chr21:47156779:D) that lies close to a collagen gene, COL18A1, showed an association with ankle injury at genome-wide significance (p = 3.8x10-8; OR = 1.99; 95% CI = 1.75-2.23). A second DNA variant (rs13286037 on chromosome 9) that lies within an intron of the transcription factor gene NFIB showed an ass
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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ankle injury prevention training Moderate
Strengthening ankle stabilizers and proprioceptive training reduce ankle injury risk in predisposed individuals.
Regular ankle strengthening and balance exercises, frequency per clinician guidance
Screening
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ankle stability and proprioception assessment Moderate
Genetic variant is associated with 62% increased ankle injury risk; baseline assessment identifies modifiable risk factors.
Evaluation with sports medicine clinician or physical therapist