Expressive

rs11771793 - SHH - Y_RNA

Magnitude 4.5 · 1 study on file

Reported associations

  • Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease - Unknown journal (n.d.) · Unknown authors · PubMed 27082954

    ABSTRACT: There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing susceptibility to these exposures. However, genome-scale investigations of these interactions have been rarely performed particularly in the case of air pollution exposures. We performed race-stratified genome-wide gene-environment interaction association studies on European-American (EA, N = 1623) and African-American (AA, N = 554) cohorts to investigate the joint influence of common single nucleotide polymorphisms (SNPs) and residential exposure to traffic ("traffic exposure")-a recognized vascular disease risk factor-on peripheral arterial disease (PAD). Traffic exposure was estimated via the dis

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • personalized PAD risk and air pollution assessment Moderate

    clinical PAD risk assessment should account for this variant's gene-environment interaction with air pollution

Lifestyle

  • traffic-related air pollution exposure Moderate

    rs11771793 shows strong gene-environment interaction with traffic pollution for peripheral arterial disease risk

    minimize time in high-traffic areas; consider air quality when selecting residence and work location

Screening

  • peripheral artery disease screening Moderate

    variant carriers have elevated peripheral arterial disease risk when exposed to traffic pollution per GWAS evidence

    discuss baseline ankle-brachial index screening with physician; consider periodic monitoring if pollution-exposed