Expressive

rs11771693 - RARRES2 - REPIN1-AS1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits - Unknown journal (n.d.) · Unknown authors · PubMed 38689001

    ABSTRACT: Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10−8) from the largest single-stage blood pressure (BP) genome-wide association study to date (n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing top versus bottom deciles of polygenic risk scores (PRSs) reveals clinically meaningful differences in BP (16.9 mmHg systolic BP, 95% CI, 15.5-18.2 mmHg, P = 2.22 × 10−126) and more than a sevenfold higher odds of hypertension risk (odds ratio, 7.33; 95% CI, 5.54-9.70; P = 4.13 × 10−44) in an independent dataset. Adding PRS into hypertension-pre

  • Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits - Unknown journal (n.d.) · Unknown authors · PubMed 30224653

    ABSTRACT: High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic, pulse pressure) to date in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. FULL TEXT: [INTRO] Introduction [INTRO] High blood pressure (BP) is a leading heritable risk factor for stroke and coronary artery disease, responsible for an es

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • discuss genetic BP predisposition and management plan High

    identified genetic BP risk warrants individualized discussion of screening frequency, lifestyle targets, and pharmacologic intervention thresholds

Exercise

  • regular aerobic exercise for blood pressure management Moderate

    aerobic exercise reduces BP especially in individuals with genetic hypertension predisposition; benefit amplified by consistent adherence

    at least 150 minutes moderate-intensity aerobic exercise per week

Lifestyle

  • reduce sodium intake for blood pressure control Moderate

    individuals with genetic predisposition to elevated BP benefit from sodium restriction; modest SNP effect size underscores lifestyle importance

    aim for sodium intake under 2300 mg daily; discuss personalized target with physician

  • weight management to reduce blood pressure Moderate

    weight loss of 5-10% reduces systolic BP significantly; effect particularly important in individuals with genetic predisposition

    maintain BMI under 25 kg/m2 or achieve 5-10% weight loss if overweight

Screening

  • blood pressure monitoring beginning at age 30 High

    rs11771693 risk alleles robustly predict 0.17 mmHg higher systolic BP per allele; effect replicated in two GWAS with 1.8M subjects

    baseline BP assessment by age 30; annual screening if normotensive; more frequent if elevated