Expressive

rs11770879 - KLHL7

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484

    ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • C-reactive protein (CRP) levels Moderate

    rs11770879-A is associated with elevated CRP, a biomarker of systemic inflammation and cardiovascular risk

    Check CRP annually; consider checking when assessing cardiovascular risk

Discuss with your doctor

  • Cardiovascular risk assessment given CRP-raising genotype Moderate

    rs11770879-A carriers have elevated CRP; discussion of baseline cardiovascular risk and monitoring strategy is warranted

    Discuss genotype-informed cardiovascular risk assessment with your healthcare provider

Lifestyle

  • Anti-inflammatory modifications for cardiovascular health Moderate

    CRP elevation is linked to cardiovascular disease risk; anti-inflammatory modifications may help reduce this risk

    Consider Mediterranean-style diet, regular aerobic exercise, weight management, stress reduction, adequate sleep