rs11770686 - HIP1
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study in essential tremor identifies three new loci - Unknown journal (n.d.) · Unknown authors · PubMed 27797806
ABSTRACT: Essential tremor has a high heritability, but its molecular genetic determinants remain unknown. Müller et al. conduct a genome-wide association study in more than 2800 patients with essential tremor and more than 6800 controls of European descent, and identify three new loci associated with the disease. We conducted a genome-wide association study of essential tremor, a common movement disorder characterized mainly by a postural and kinetic tremor of the upper extremities. Twin and family history studies show a high heritability for essential tremor. The molecular genetic determinants of essential tremor are unknown. We included 2807 patients and 6441 controls of European descent in our two-stage genome-wide association study. The 59 most significantly disease-associated marker
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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clinical tremor assessment and monitoring Moderate
rs11770686-T allele is associated with increased essential tremor risk; early detection enables treatment decisions.
baseline neurological tremor evaluation; periodic reassessment if tremor symptoms develop