Expressive

rs117704951 - ANKIB1

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability - Unknown journal (n.d.) · Unknown authors · PubMed 30120083

    ABSTRACT: Background Circadian rhythms are fundamental to health and are particularly important for mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder. Methods We conducted a genome-wide association study (GWAS) of low relative amplitude (RA), an objective measure of rest-activity cycles derived from the accelerometer data of 71,500 UK Biobank participants. Polygenic risk scores (PRS) for low RA were used to investigate potential associations with psychiatric phenotypes. Outcomes Two independent genetic loci were associated with low RA, within genomic regions for Neurofascin (NFASC) and Solute Carrier Family 25 Member 17 (SLC25A17). A secondary GWAS of RA as a continuous measure identified a locus withi

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • circadian rhythm assessment and sleep disorder evaluation Moderate

    This variant associates with circadian rhythm disruption; professional assessment can identify and manage sleep disorders

Lifestyle

  • sleep schedule consistency with morning light Moderate

    ANKIB1 variant associates with low-amplitude circadian rhythms; consistent timing and morning light help entrain circadian phase

    Maintain consistent bed and wake times; get outdoor light within 2 hours of waking each day

Screening

  • sleep quality and circadian rhythm consistency Moderate

    Circadian disruption often manifests as irregular sleep-wake patterns; tracking helps identify sleep disorders

    Track sleep and wake times for 2-4 weeks; consider wearable actigraphy if available