rs11769948 - FOXP2 - MDFIC
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914
Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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sleep patterns and insomnia risk Moderate
rs11769948-T is genetically associated with insomnia; clinical assessment may guide management
Lifestyle
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sleep hygiene optimization Moderate
rs11769948-T increases insomnia predisposition; structured sleep practices improve outcomes
consistent sleep/wake schedule, dark and cool bedroom, no screens 1 hour before bed
Screening
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insomnia symptoms and sleep quality High
rs11769948-T allele associates with increased insomnia risk in large GWAS (n=2.3M)
regular sleep quality self-assessment; report patterns to physician