rs11769064 - EEF1B2P6 - NDUFB9P2

Magnitude 2.0 · 1 study on file

Reported associations

• Genetic variants associated with longitudinal changes in brain structure across the lifespan - Unknown journal (n.d.) · Unknown authors · PubMed 35383335

  ABSTRACT: Human brain structure changes throughout our lives. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental, and neurodegenerative diseases. Here, we identified common genetic variants that affect rates of brain growth or atrophy, in the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal MRI data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene-set findings implicate both early brain development and ne

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