rs11768686 - LINC01162

Magnitude 2.2 · 1 study on file

Reported associations

• Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels - Unknown journal (n.d.) · Unknown authors · PubMed 35396452

  ABSTRACT: Circulating total-tau levels can be used as an endophenotype to identify genetic risk factors for tauopathies and related neurological disorders. Here, we confirmed and better characterized the association of the 17q21 MAPT locus with circulating total-tau in 14,721 European participants and identified three novel loci in 953 African American participants (4q31, 5p13, and 6q25) at P < 5 × 10−8. We additionally detected 14 novel loci at P < 5 × 10−7, specific to either Europeans or African Americans. Using whole-exome sequence data in 2,279 European participants, we identified ten genes associated with circulating total-tau when aggregating rare variants. Our genetic study sheds light on genes reported to be associated with neurological diseases including str

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