rs11766965 - PRELID3BP10 - ZNF800
Magnitude 4.5 · 1 study on file
Reported associations
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Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. - Nature genetics (2019) · Nagel M, Jansen PR, Stringer S, Watanabe K, de Leeuw CA, Bryois J, Savage JE, Hammerschlag AR, Skene NG, Muñoz-Manchado AB, White T, Tiemeier H, Linnarsson S, Hjerling-Leffler J, Polderman TJC, Sullivan PF, van der Sluis S, Posthuma D · PubMed 29942085
Neuroticism is an important risk factor for psychiatric traits, including depression , anxiety , and schizophrenia . At the time of analysis, previous genome-wide association studies (GWAS) reported 16 genomic loci associated to neuroticism . Here we conducted a large GWAS meta-analysis (n = 449,484) of neuroticism and identified 136 independent genome-wide significant loci (124 new at the time of analysis), which implicate 599 genes. Functional follow-up analyses showed enrichment in several brain regions and involvement of specific cell types, including dopaminergic neuroblasts (P = 3.49 × 10 ), medium spiny neurons (P = 4.23 × 10 ), and serotonergic neurons (P = 1.37 × 10 ). Gene set analyses implicated three specific pathways: neurogenesis (P = 4.43
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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regular aerobic exercise Moderate
Exercise reduces anxiety and mood symptoms in individuals with elevated neuroticism traits.
150 minutes moderate-intensity aerobic exercise per week
Screening
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mental health screening for anxiety and depression Moderate
Variants at this locus are associated with increased neuroticism, a trait linked to higher anxiety and depression risk.
Annual screening with standardized questionnaires (PHQ-9, GAD-7)