rs11765845 - CREB5

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide meta-analysis for severe diabetic retinopathy. - Human molecular genetics (2011) · Grassi MA, Tikhomirov A, Ramalingam S, Below JE, Cox NJ, Nicolae DL · PubMed 21441570

  Diabetic retinopathy is a leading cause of blindness. The purpose of this study is to identify novel genetic loci associated with the sight threatening complications of diabetic retinopathy. We performed a meta-analysis of genome-wide association data for severe diabetic retinopathy as defined by diabetic macular edema or proliferative diabetic retinopathy in unrelated cases ascertained from two large, type I diabetic cohorts: the Genetics of Kidney in Diabetes (GoKinD) and the Epidemiology of Diabetes Intervention and Control Trial (EDIC) studies. Controls were other diabetic subjects in the cohort. A combined total of 2829 subjects (973 cases, 1856 controls) were studied on 2 543 887 single nucleotide polymorphisms (SNPs). Subjects with nephropathy were excluded in a sub-analysis of 281

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