Expressive

rs11765552 - LMTK2

Magnitude 2.2 · 2 studies on file

Reported associations

  • Urate, Blood Pressure, and Cardiovascular Disease - Unknown journal (n.d.) · Unknown authors · PubMed 33356394

    ABSTRACT: Supplemental Digital Content is available in the text. Serum urate has been implicated in hypertension and cardiovascular disease, but it is not known whether it is exerting a causal effect. To investigate this, we performed Mendelian randomization analysis using data from UK Biobank, Million Veterans Program and genome-wide association study consortia, and meta-analysis of randomized controlled trials. The main Mendelian randomization analyses showed that every 1-SD increase in genetically predicted serum urate was associated with an increased risk of coronary heart disease (odds ratio, 1.19 [95% CI, 1.10-1.30]; P=4×10−5), peripheral artery disease (1.12 [95% CI, 1.03-1.21]; P=9×10−3), and stroke (1.11 [95% CI, 1.05-1.18]; P=2×10−4). In Mendelian randomization med

  • Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups - Unknown journal (n.d.) · Unknown authors · PubMed 39930085

    ABSTRACT: We conducted a multiancestry genome-wide association study of prostate-specific antigen (PSA) levels in 296,754 men (211,342 European ancestry, 58,236 African ancestry, 23,546 Hispanic/Latino and 3,630 Asian ancestry; 96.5% of participants were from the Million Veteran Program). We identified 318 independent genome-wide significant (P ≤ 5 × 10−8) variants, 184 of which were novel. Most demonstrated evidence of replication in an independent cohort (n = 95,768). Meta-analyzing discovery and replication (n = 392,522) identified 447 variants, of which a further 111 were novel. Out-of-sample variance in PSA explained by our genome-wide polygenic risk scores ranged from 11.6% to 16.6% for European ancestry, 5.5% to 9.5% for African ancestry, 13.5% to 18.2% for Hispanic

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Serum urate levels Moderate

    LMTK2 rs11765552 A allele associated with elevated serum urate in large GWAS

    Check baseline at next physical; monitor annually

Diet

  • High-fructose beverages Moderate

    High fructose intake increases urate production; relevant for genetically elevated phenotype

    Avoid sugar-sweetened beverages; limit fruit juice to occasional use

  • High-purine foods Moderate

    Dietary purine reduction lowers serum urate; key strategy for genetically elevated phenotype

    Limit red meat to 2-3 times weekly; avoid organ meats and high-purine seafood

Discuss with your doctor

  • Urate-lowering therapy and gout prevention Moderate

    LMTK2 variant increases gout risk through elevated urate; medical assessment needed in high-risk

    Discuss baseline urate levels, gout symptoms, and potential urate-lowering medication options

Lifestyle

  • Weight management and physical activity Moderate

    Obesity associated with elevated urate; weight loss reduces urate in genetically predisposed

    Target BMI 18.5-24.9; 150 minutes moderate aerobic activity weekly