rs11764116 - HDAC9

Magnitude 2.0 · 1 study on file

Reported associations

• Genetic Predictors of Medically Refractory Ulcerative Colitis - Inflammatory bowel diseases (2011) · Haritunians T, Taylor KD, Targan SR, Dubinsky M, Ippoliti A, Kwon S, Guo X, Melmed GY, Berel D, Mengesha E, Psaty BM, Glazer NL, Vasiliauskas EA, Rotter JI, Fleshner PR, McGovern DP · PubMed 20848476

  ABSTRACT: Background Acute severe ulcerative colitis (UC) remains a significant clinical challenge and the ability to predict, at an early stage, those individuals at risk of colectomy for medically refractory UC (MR-UC) would be a major clinical advance. The aim of this study was to use a genome-wide association study (GWAS) in a well-characterized cohort of UC patients to identify genetic variation that contributes to MR-UC. Methods A GWAS comparing 324 MR-UC patients with 537 Non-MR-UC patients was analyzed using logistic regression and Cox proportional hazards methods. In addition, the MR-UC patients were compared with 2601 healthy controls. Results MR-UC was associated with more extensive disease (p= 2.7×10−6) and a positive family history of UC (p= 0.004). A risk score based on th

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