rs117640426 - MIR4302 - RASSF8-AS1

Magnitude 4.5 · 1 study on file

Reported associations

• Heritability of Atrial Fibrillation - Unknown journal (n.d.) · Unknown authors · PubMed 29237688

  ABSTRACT: Background Previous reports have implicated multiple genetic loci associated with atrial fibrillation (AF), but the contributions of genome-wide variation to AF susceptibility have not been quantified. Methods and Results We assessed the contribution of genome-wide single nucleotide polymorphism (SNP) variation to AF risk (SNP-heritability, h2g) using data from 120,286 unrelated individuals of European ancestry (2,987 with AF) in the population-based UK Biobank. We ascertained AF based on self-report, medical record billing codes, procedure codes, and death records. We estimated h2g using a variance components method with variants having a minor allele frequency (MAF) ≥1%. We evaluated h2g in age, sex, and genomic strata of interest. The h2g for AF was 22.1% (95% CI 15.6%-28.

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