rs117636523 - RN7SL292P - SGO1P2

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic Variants in the Gene Are Associated with Thyroglobulin Plasma Level in Healthy Individuals. - Thyroid : official journal of the American Thyroid Association (2020) · Matana A, Popović M, Boutin T, Torlak V, Brdar D, Gunjača I, Kolčić I, Boraska Perica V, Punda A, Rudan I, Polašek O, Barbalić M, Hayward C, Zemunik T · PubMed 30929638

  Thyroglobulin (Tg) is a 660 kDa iodoglycoprotein that serves as a scaffold for thyroid hormone synthesis. Although a twin study showed that variability of serum Tg levels has a substantial genetic basis, no genome-wide association study (GWAS) of serum/plasma Tg levels has been performed to date. The aim of this study was to identify genetic variants associated with plasma Tg levels among healthy individuals. A GWAS was conducted on two Croatian cohorts, and a combined analysis was performed. The analyses included 1094 individuals. A total of 7,597,379 variants, imputed using the 1000 Genomes reference panel, were analyzed for association. GWAS was performed under an additive model, controlling for age, sex, and relatedness within each data set. Combined analysis was conducted using the

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