rs11762636 - MAD1L1
Magnitude 2.2 · 1 study on file
Reported associations
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Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis - Unknown journal (n.d.) · Unknown authors · PubMed 34187846
ABSTRACT: Objective Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology primarily attributable to its symptom-based definitions. GERD genome-wide association studies (GWASs) have shown strong genetic overlaps with established risk factors such as obesity and depression. We hypothesised that the shared genetic architecture between GERD and these risk factors can be leveraged to (1) identify new GERD and Barrett's oesophagus (BE) risk loci and (2) explore potentially heterogeneous pathways leading to GERD and oesophageal complications. Design We applied multitrait GWAS models combining GERD (78 707 cases; 288 734 controls) and genetically correlated traits including education attainment, depression and body mass index. We also used multitrait analysis to identify BE ri
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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GERD risk and prevention strategy Moderate
C allele at rs11762636 is significantly associated with increased GERD risk (n=602,604, p<0.001)
Discuss personal and family GERD history; develop individualized prevention and screening plan
Screening
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GERD symptoms and esophageal reflux Moderate
Elevated genetic predisposition from rs11762636 supports heightened surveillance for reflux symptoms
Monitor for heartburn, regurgitation, or dysphagia; report new or persistent symptoms to physician