rs117609474 - LINC02331, DDHD1-DT

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-Wide Association Study of Alzheimer Disease Endophenotypes at Prediagnosis Stages - Unknown journal (n.d.) · Unknown authors · PubMed 29274321

  ABSTRACT: INTRODUCTION Genetic associations for endophenotypes of Alzheimer's disease (AD) in cognitive stages preceding Alzheimer disease have not been thoroughly evaluated. METHODS We conducted GWAS for AD-related endophenotypes including hippocampal volume (HPV), logical memory scores (LMT), and cerebrospinal fluid (CSF) amyloid β42 and total/phosphorylated tau (t-/p-Tau) in cognitively normal (CN), mild cognitive impairment (MCI), and AD dementia subjects from the Alzheimer's Disease Neuroimaging Initiative study. RESULTS In CN subjects, study-wide significant (SWS; P<8.3×10−9) loci were identified for t-Tau near SRRM4 and C14orf79 and for HPV near MTUS1. In MCI subjects, SWS association was found with SNPs near ZNF804B for LMT-delayed recall. We found consistent expression pat

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