rs117607728 - PLCE1
Magnitude 2.2 · 1 study on file
Reported associations
-
Genome-wide association study of smoking behaviors in COPD patients - Unknown journal (n.d.) · Unknown authors · PubMed 21685187
ABSTRACT: Background Cigarette smoking is a major risk factor for COPD and COPD severity. Previous genome-wide association studies (GWAS) have identified numerous single nucleotide polymorphisms (SNPs) associated with the number of cigarettes smoked per day (CPD) and a Dopamine Beta-Hydroxylase (DBH) locus associated with smoking cessation in multiple populations. Objective To identify SNPs associated with lifetime average and current CPD, age at smoking initiation, and smoking cessation in COPD subjects. Methods GWAS were conducted in 4 independent cohorts encompassing 3,441 ever-smoking COPD subjects (GOLD stage II or higher). Untyped SNPs were imputed using HapMap (phase II) panel. Results from all cohorts were meta-analyzed. Results Several SNPs near the HLA region on chromosome 6p21 a
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
-
smoking and high-intensity smoking patterns Moderate
T allele carriers show higher daily cigarette consumption in COPD cohorts, suggesting predisposition to heavier smoking or nicotine dependence
Minimize or eliminate cigarette smoking; if currently smoking, pursue cessation strategies
Screening
-
spirometry and respiratory function testing Moderate
Variant associated with higher smoking intensity in COPD patients, suggesting heightened susceptibility to smoking-related airway disease
Discuss baseline spirometry with primary care provider, especially if current or former smoker