rs117565216 - NNT - RNU6-381P

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide study of subcutaneous and visceral adipose tissue reveals novel sex-specific adiposity loci in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study - Unknown journal (n.d.) · Unknown authors · PubMed 29178545

  ABSTRACT: Objective This study aimed to explore genetic mechanisms of regional fat deposition, which is a strong risk factor for metabolic diseases beyond total adiposity. Methods A genome-wide association study of 7,757,139 SNPs in 983 Mexican Americans (Nmale=403, Nfemale=580) from the Insulin Resistance Atherosclerosis Family Study (IRASFS) was performed. Association analyses were performed with and without sex stratification for subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and visceral-subcutaneous ratio (VSR) obtained from computed tomography (CT). Results The strongest signal identified was SNP rs2185405 (MAF=40%, PVAT=1.98×10-8) with VAT. It is an intronic variant of the GLIS family zinc finger 3 gene (GLIS3). In addition, SNP rs12657394 (MAF=19%) was associate

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