rs117556552 - ANO3

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages. - Alzheimer's & dementia : the journal of the Alzheimer's Association (2019) · Chung J, Wang X, Maruyama T, Ma Y, Zhang X, Mez J, Sherva R, Takeyama H, Lunetta KL, Farrer LA, Jun GR · PubMed 29274321

  Genetic associations for endophenotypes of Alzheimer's disease (AD) in cognitive stages preceding AD have not been thoroughly evaluated. We conducted genome-wide association studies for AD-related endophenotypes including hippocampal volume, logical memory scores, and cerebrospinal fluid Aβ and total/phosphorylated tau in cognitively normal (CN), mild cognitive impairment, and AD dementia subjects from the Alzheimer's Disease Neuroimaging Initiative study. In CN subjects, study-wide significant (P < 8.3 × 10 ) loci were identified for total tau near SRRM4 and C14orf79 and for hippocampal volume near MTUS1. In mild cognitive impairment subjects, study-wide significant association was found with single nucleotide polymorphisms (SNPs) near ZNF804B for logical memory test of delayed reca

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