rs11755054 - LINC03005, CASC15
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-Wide Association Studies and Meta-Analyses for Congenital Heart Defects - Unknown journal (n.d.) · Unknown authors · PubMed 28468790
ABSTRACT: Background Maternal and inherited (i.e., case) genetic factors likely contribute to the etiology of congenital heart defects, but it is unclear whether individual common variants confer a large risk. Methods and Results To evaluate the relationship between individual common maternal/inherited genotypes and risk for heart defects, we conducted genome-wide association studies (GWAS) in five cohorts. Three cohorts were recruited at the Children's Hospital of Philadelphia: 670 conotruncal heart defect (CTD) case-parent trios; 317 left ventricular obstructive tract defect (LVOTD) case-parent trios; and 406 CTD cases and 2,976 pediatric controls. Two cohorts were recruited through the Pediatric Cardiac Genomics Consortium: 355 CTD trios and 192 LVOTD trios. We also conducted meta-ana
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to left ventricular obstruction Moderate
GWAS finding establishes significant genetic association with left ventricular obstructive tract defect.
Discuss this genetic finding with a cardiologist to develop personalized screening and management plan.
Screening
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echocardiographic cardiac screening Moderate
Genetic association with left ventricular obstructive tract defect indicates increased risk for this structural cardiac condition.
Discuss with cardiologist to determine appropriate timing and frequency of cardiac imaging.