Expressive

rs117545698 - EXOC6

Magnitude 2.2 · 1 study on file

Reported associations

  • Pleiotropic genetic architecture and novel loci for C-reactive protein levels - Unknown journal (n.d.) · Unknown authors · PubMed 36376304

    ABSTRACT: C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes supporting common biological pathways between inflammation and metabolic traits. To identify novel pleiotropic loci, we perform multi-trait analysis of genome-wide association studies on C-reactive protein levels along with cardiometabolic traits, followed by a series of in silico analyses including colocalization, phenome-wide association studies and Mendelian randomization. We find 41 novel loci and 19 gene sets associated with C-reactive protein with various pleiotropic effects. Additionally, 41 variants colocalize between C-reactive protein and cardiometabolic risk factors and 12 of them display

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Fasting triglyceride levels Moderate

    EXOC6 rs117545698 A allele associated with elevated triglyceride levels in large GWAS

    Annual or biennial fasting lipid panel including triglycerides

Diet

  • Refined carbohydrates and added sugars Moderate

    Reducing refined carbohydrates decreases triglyceride production, particularly important for genetic carriers

    Limit to under 10% of daily calories

Discuss with your doctor

  • Triglyceride management and treatment targets Moderate

    EXOC6 rs117545698 A allele carriers have elevated triglyceride risk requiring personalized management

    Discuss target triglyceride levels and need for pharmacotherapy if lifestyle modifications insufficient

Exercise

  • Aerobic exercise Moderate

    Aerobic exercise reduces triglyceride levels, especially important for those with genetic predisposition to hypertriglyceridemia

    150 minutes moderate-intensity aerobic activity per week