rs11754507 - DSE
Magnitude 2.2 · 1 study on file
Reported associations
-
Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland - Unknown journal (n.d.) · Unknown authors · PubMed 30718454
ABSTRACT: Stress is associated with poorer physical and mental health. To improve our understanding of this link, we performed genome-wide association studies (GWAS) of depressive symptoms and genome-wide by environment interaction studies (GWEIS) of depressive symptoms and stressful life events (SLE) in two UK population-based cohorts (Generation Scotland and UK Biobank). No SNP was individually significant in either GWAS, but gene-based tests identified six genes associated with depressive symptoms in UK Biobank (DCC, ACSS3, DRD2, STAG1, FOXP2 and KYNU; p < 2.77 × 10−6). Two SNPs with genome-wide significant GxE effects were identified by GWEIS in Generation Scotland: rs12789145 (53-kb downstream PIWIL4; p = 4.95 × 10−9; total SLE) and rs17070072 (intronic to ZCCHC2
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
-
Structured stress management practice Moderate
The SNP's depression risk effect is specific to exposure to stressful life events, indicating stress reduction strategies address the primary risk pathway
Regular stress-reduction practice, such as meditation or therapy, 3-5 times weekly
Screening
-
Depression screening Moderate
Carriers of the G risk allele show increased depressive symptom susceptibility in response to stressful life events (p < 1e-6, n=4919)
Annual or semi-annual mental health assessment, especially during stressful periods