rs11753937 - EYA4
Magnitude 2.2 · 1 study on file
Reported associations
-
GENOMIC ASSOCIATION ANALYSIS IDENTIFIES MULTIPLE LOCI INFLUENCING ANTIHYPERTENSIVE RESPONSE TO AN ANGIOTENSIN II RECEPTOR BLOCKER - Unknown journal (n.d.) · Unknown authors · PubMed 22566498
ABSTRACT: To identify genes influencing blood pressure response to an angiotensin II receptor blocker, single nucleotide polymorphisms identified by genome-wide association analysis of the response to candesartan were validated by opposite direction associations with the response to a thiazide diuretic, hydrochlorothiazide. 198 White and 193 African Americans with primary hypertension were sampled from opposite tertiles of the race-sex-specific distributions of age-adjusted diastolic blood pressure response to candesartan. 285 polymorphisms associated with the response to candesartan at p<10−4 in Whites. 273 of the 285 polymorphisms, which were available for analysis in a separate sample of 196 Whites, validated for opposite direction associations with the response to hydrochlorothiazide
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
Discuss ARB therapy response with physician Moderate
The T allele is associated with improved response to angiotensin II receptor blocker therapy
If ARB therapy is recommended, mention your EYA4 rs11753937 T allele status