rs117533208 - DCBLD1

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study identifying novel variant for fasting insulin and allelic heterogeneity in known glycemic loci in Chilean adolescents: The Santiago Longitudinal Study - Unknown journal (n.d.) · Unknown authors · PubMed 33381925

  ABSTRACT: Background: The genetic underpinnings of glycemic traits have been understudied in adolescent and Hispanic/Latino (H/L) populations in comparison to adults and populations of European ancestry. Objective: To identify genetic factors underlying glycemic traits in an adolescent H/L population. Methods: We conducted a genome-wide association study (GWAS) of fasting glucose (FG) and fasting insulin (FI) in H/L adolescents from the Santiago Longitudinal Study. Results: We identified one novel variant positioned in the CSMD1 gene on chromosome 8 (rs77465890, effect allele frequency=0.10) that was associated with FI (β=−0.299, SE=0.054, p=2.72×10−8) and was only slightly attenuated after adjusting for body mass index z-scores (β=−0.252, SE=0.047, p=1.03×10−7). We demonstrate

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