rs117529685 - NOC3L

Magnitude 2.2 · 1 study on file

Reported associations

• A genome-wide association study of 24-hour urinary excretion of endocrine disrupting chemicals. - Environment international (2024) · Lu X, van der Meer TP, Kamali Z, van Faassen M, Kema IP, van Beek AP, Xu X, Huo X, Ani A, Nolte IM, Wolffenbuttel BHR, van Vliet-Ostaptchouk JV, Snieder H · PubMed 38150807

  Ubiquitous exposure to environmental endocrine disrupting chemicals (EDCs) instigates a major public health problem, but much remains unknown on the inter-individual differences in metabolism and excretion of EDCs. To examine this we performed a two-stage genome-wide association study (GWAS) for 24-hour urinary excretions of four parabens, two bisphenols, and nine phthalate metabolites. Results showed five genome-wide significant (p-value < 5x10 ) and replicated single nucleotide polymorphisms (SNPs) representing four independent signals that associated with mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP) and mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP). Three of the four signals were located on chromosome 10 in a locus harboring the cytochrome P450 (CYP) genes CYP2C9, CYP2C58P, and

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