rs117526881 - MYH7 - NGDN
Magnitude 2.2 · 2 studies on file
Reported associations
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A scalable variational inference approach for increased mixed-model association power - Unknown journal (n.d.) · Unknown authors · PubMed 39789286
ABSTRACT: The rapid growth of modern biobanks is creating new opportunities for large-scale genome-wide association studies (GWASs) and the analysis of complex traits. However, performing GWASs on millions of samples often leads to trade-offs between computational efficiency and statistical power, reducing the benefits of large-scale data collection efforts. We developed Quickdraws, a method that increases association power in quantitative and binary traits without sacrificing computational efficiency, leveraging a spike-and-slab prior on variant effects, stochastic variational inference and graphics processing unit acceleration. We applied Quickdraws to 79 quantitative and 50 binary traits in 405,088 UK Biobank samples, identifying 4.97% and 3.25% more associations than REGENIE and 22.71%
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Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease - Unknown journal (n.d.) · Unknown authors · PubMed 36918541
ABSTRACT: The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanni
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Cardiac arrhythmia risk and monitoring strategy Moderate
Elevated spQRSTa from this variant is associated with conduction disease, atrial fibrillation, and sudden cardiac death risk.
Discuss baseline arrhythmia risk assessment and long-term monitoring plan with cardiologist
Screening
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Baseline ECG with spatial QRS-T angle assessment Moderate
rs117526881 is the strongest genetic variant for spatial QRS-T angle; abnormal values predict increased arrhythmia and sudden cardiac death risk.
Request 12-lead ECG with spatial QRS-T angle calculation; review results with cardiologist