Expressive

rs11752386 - MDGA1

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914

    Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic predisposition to insomnia and preventive strategy Moderate

    Genetic risk requires medical evaluation to establish appropriate monitoring interval and early intervention if symptoms develop

Exercise

  • Regular daytime aerobic activity Moderate

    Physical activity improves sleep quality and duration; timing in early part of day optimizes benefit for sleep onset

    150+ minutes per week moderate-intensity aerobic exercise, completed by early evening, at least 3 hours before bed

Lifestyle

  • Sleep hygiene optimization Moderate

    Consistent sleep routines and optimized sleep environment improve sleep quality; beneficial for those with genetic predisposition

    Maintain consistent bedtime and wake time; keep room dark, cool (65-68F), and quiet; avoid screens 1 hour before bed

Screening

  • Sleep quality and insomnia symptoms Moderate

    Variant associated with increased insomnia risk in large GWAS cohort; early detection enables timely intervention

    Track sleep duration, latency, and quality; document patterns of difficulty falling or staying asleep