rs117518238 - BCAS3, TBX2-AS1
Magnitude 2.8 · 1 study on file
Reported associations
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Central Adiposity Increases Risk of Kidney Stone Disease through Effects on Serum Calcium Concentrations - Unknown journal (n.d.) · Unknown authors · PubMed 37787550
ABSTRACT: Visual Abstract Significance Statement Kidney stone disease is a common disorder with poorly understood pathophysiology. Observational and genetic studies indicate that adiposity is associated with an increased risk of kidney stone disease. However, the relative contribution of general and central adipose depots and the mechanisms by which effects of adiposity on kidney stone disease are mediated have not been defined. Using conventional and genetic epidemiological techniques, we demonstrate that general and central adiposity are independently associated with kidney stone disease. In addition, one mechanism by which central adiposity increases risk of kidney stone disease is by increasing serum calcium concentration. Therapies targeting adipose depots may affect calcium homeostas
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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kidney stone disease prevention strategy Moderate
Genetic predisposition to kidney stone disease warrants personalized risk reduction counseling
Lifestyle
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reduce central adiposity Moderate
Central adiposity (abdominal/waist fat) is causally linked to kidney stone disease through increased serum calcium concentrations
Target waist circumference reduction; discuss weight management strategy with healthcare provider
Screening
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kidney stone disease screening Moderate
Genetic variant rs117518238 (BCAS3) significantly increases kidney stone disease risk (OR=1.21, p=8.44e-10)
Discuss screening strategy with healthcare provider; consider baseline imaging such as ultrasound or CT