Expressive

rs117511642 - CLNS1AP1 - RPL10P10

Magnitude 2.2 · 1 study on file

Reported associations

  • Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population - Unknown journal (n.d.) · Unknown authors · PubMed 40465716

    ABSTRACT: We addressed the underrepresentation of non-European populations in genome-wide association studies (GWASs) by building HiGenome, a large-scale genetic resource for the Taiwanese Han population. Using a custom genotyping array, we integrated deidentified electronic medical records (2003 to 2021) with genomic data to enable GWASs, phenome-wide association studies, and polygenic risk score (PRS) analysis. Among 413,000 participants, 323,397 passed ancestry and quality control filtering. GWASs covered 1085 traits, focusing on diseases prevalent in Taiwan such as type 2 diabetes, chronic kidney disease, gout, and alcoholic liver damage. PRSs were calculated for 238 traits, with the strongest associations observed in musculoskeletal disorders. Incorporating PRS into clinical practice

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • beer and distilled spirits Moderate

    Alcohol reduces uric acid excretion and increases purine metabolism, elevating gout risk

    Limit to <=1 drink per day for women, <=2 per day for men; avoid if recurrent attacks

  • high-fructose foods and beverages Moderate

    Fructose increases hepatic purine synthesis and uric acid production, worsening gout risk

    Limit sugar-sweetened drinks; choose water, unsweetened tea, black coffee instead

  • high-purine foods Moderate

    Purines metabolize to uric acid; elevated serum uric acid precipitates gout in genetically susceptible individuals

    Limit organ meats, red meat, anchovies, sardines to 1-2 servings per week

Discuss with your doctor

  • genetic gout predisposition and management Moderate

    This variant increases gout risk; individualized management reduces attack frequency and chronic complications

    Discuss uric acid targets and consider xanthine oxidase inhibitor or uricosuric if attacks recur

Lifestyle

  • adequate hydration for uric acid excretion Moderate

    Dehydration concentrates serum uric acid; adequate hydration enhances renal urate excretion

    Drink 2.5-3.5 liters water daily; more with exercise or heat exposure

  • gradual weight loss if overweight Moderate

    Obesity increases serum uric acid through purine turnover and reduced renal excretion

    Target BMI 18.5-24.9; aim for 0.5-1 pound per week loss if overweight

Screening

  • serum uric acid level screening Moderate

    Elevated uric acid predicts gout attacks; monitoring identifies need for prophylactic therapy

    Check serum uric acid baseline and annually; recheck if uric acid >6.8 mg/dL or attacks occur