rs117500377 - Y_RNA - HEATR5A

Magnitude 2.0 · 1 study on file

Reported associations

• Genetic pleiotropy between pulmonary function and age-related traits: The Long Life Family Study. - The journals of gerontology. Series A, Biological sciences and medical sciences (2026) · Feitosa MF, Wojczynski MK, Anema JA, Daw EW, Wang L, Santanasto AJ, Nygaard M, Province MA · PubMed 35180297

  Pulmonary function (PF) progressively declines with aging. Forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) are predictors of morbidity of pulmonary and cardiovascular diseases and all-cause mortality. In addition, reduced PF is associated with elevated chronic low-grade systemic inflammation, glucose metabolism, body fatness, and low muscle strength. It may suggest pleiotropic genetic effects between PF with these age-related factors. We evaluated whether FEV1 and FVC share common pleiotropic genetic effects factors with interleukin-6, high-sensitivity C-reactive protein, body mass index, muscle (grip) strength, plasma glucose, and glycosylated hemoglobin in 3,888 individuals (age range: 26-106). We employed sex-combined and sex-specific correlated meta-

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