rs117490883 - EPC2
Magnitude 4.5 · 1 study on file
Reported associations
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Trans-ethnic association study of blood pressure determinants in over 750,000 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 30578418
ABSTRACT: In this trans-ethnic multi-omic study we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenome, and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in GWASs of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically-predicted gene expression of 840 genes in 45 tissues, and murine renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells. Editorial summary: Analysis of blood pressure data from
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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sodium restriction for pulse pressure management High
Dietary sodium increases arterial stiffness and pulse pressure; restriction is particularly important given genetic predisposition to elevated pulse pressure.
Limit sodium intake to less than 2300 mg per day; consider further reduction to 1500 mg if tolerated
Discuss with your doctor
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arterial stiffness screening and management strategy High
Genetic predisposition to increased pulse pressure warrants clinical assessment for arterial stiffness and discussion of individualized prevention strategies.
Exercise
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aerobic exercise for arterial stiffness reduction High
Aerobic exercise improves endothelial function and reduces arterial stiffness, directly addressing the pathophysiology underlying elevated pulse pressure.
150 minutes per week of moderate-intensity aerobic activity such as brisk walking, running, or swimming
Lifestyle
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stress management for blood pressure control Moderate
Chronic stress elevates pulse pressure through sympathetic activation; stress reduction improves arterial compliance especially in genetically predisposed individuals.
Regular meditation, yoga, or relaxation techniques; aim for 10-15 minutes daily
Screening
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pulse pressure measurement High
Genetic variant associated with increased pulse pressure indicates need for monitoring of this independent cardiovascular risk factor and marker of arterial stiffness.
Measure pulse pressure at routine health checkups