rs11748834 - HCN1 - EMB
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Prioritize low glycemic index foods Moderate
Genetic predisposition to impaired glucose metabolism can be partially offset through dietary carbohydrate quality
Emphasize whole grains, legumes, vegetables; limit refined carbohydrates
Exercise
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Aerobic exercise for glycemic control Moderate
Physical activity improves insulin sensitivity and glucose utilization, mitigating genetic diabetes risk
150 minutes per week of moderate-intensity aerobic activity
Screening
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Blood glucose and HbA1c screening Moderate
rs11748834-C allele is associated with increased diabetes risk and elevated HbA1c in large GWAS cohort
Annual fasting glucose and HbA1c testing starting in early adulthood