rs11747772 - TENM2

Magnitude 2.2 · 1 study on file

Reported associations

• Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci - Unknown journal (n.d.) · Unknown authors · PubMed 30617275

  ABSTRACT: Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and smoking cessation in a fixed effects meta-analysis of up to 61 studies (up to 346,813 participants). In a subset of 112,811 participants, a further one million SNVs were also genotyped and tested for association with the four smoking behaviour traits. SNV-trait associations with P < 5 × 10−8 in either analysis were taken forward for replication in up to 275,596 independent part

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