rs11745652 - IPO11 - ISCA1P1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-Wide Association Study of Response to Selenium Supplementation and Circulating Selenium Concentrations in Adults of European Descent. - The Journal of nutrition (2021) · Batai K, Trejo MJ, Chen Y, Kohler LN, Lance P, Ellis NA, Cornelis MC, Chow HS, Hsu CH, Jacobs ET · PubMed 33382417

  Selenium (Se) is a trace element that has been linked to many health conditions. Genome-wide association studies (GWAS) have identified variants for blood and toenail Se levels, but no GWAS has been conducted to date on responses to Se supplementation. A GWAS was performed to identify the single nucleotide polymorphisms (SNPs) associated with changes in Se concentrations after 1 year of supplementation. A GWAS of basal plasma Se concentrations at study entry was conducted to evaluate whether SNPs for Se responses overlap with SNPs for basal Se levels. A total of 428 participants aged 40-80 years of European descent from the Selenium and Celecoxib Trial (Sel/Cel Trial) who received daily supplementation with 200 µg of selenized yeast were included for the GWAS of responses to supplementat

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