Expressive

rs117453824 - SOX5

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484

    ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • anti-inflammatory diet pattern Moderate

    Variant associated with elevated CRP; dietary choices affect inflammatory markers

    emphasize whole grains, fish, vegetables, nuts; reduce refined carbohydrates

Discuss with your doctor

  • genetic predisposition to elevated CRP and bilirubin Moderate

    Variant shows strong associations with inflammatory and liver biomarkers

Exercise

  • regular aerobic exercise Moderate

    Exercise reduces CRP and systemic inflammation; variant predicts elevated baseline CRP

    150 minutes moderate-intensity aerobic exercise weekly

Screening

  • CRP and lipid panel baseline Moderate

    Genetic variant predicts higher baseline CRP, a cardiovascular inflammation biomarker

    obtain baseline CRP and lipid panel; consider annual monitoring

  • liver function panel baseline Moderate

    Genetic variant associated with elevated total bilirubin levels

    obtain baseline total and direct bilirubin and liver enzymes