Expressive

rs11742813 - ITGA2-AS1

Magnitude 2.2 · 1 study on file

Reported associations

  • Translational genomics of osteoarthritis in 1,962,069 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 40205036

    ABSTRACT: Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent associations, 513 of which have not been previously reported. Using single-cell multiomics data, we identify signal enrichment in embryonic skeletal development pathways. We integrate orthogonal lines of evidence, including transcriptome, proteome and epigenome profiles of primary joint tiss

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Osteoarthritis risk stratification and prevention Moderate

    T allele increases osteoarthritis risk (OR 1.025-1.030); ITGA2 mediates cell-matrix interactions critical for cartilage health

    Review family history, prior injuries, activity level, and BMI; discuss screening and prevention strategies

Exercise

  • Regular low-impact exercise for joint health Moderate

    Controlled movement preserves cartilage and joint function; particularly important given genetic predisposition to osteoarthritis

    150 min/week moderate activity: non-impact (swimming, cycling) or strength training with proper form

Screening

  • Early osteoarthritis detection and surveillance Moderate

    Genetic predisposition warrants vigilance for early signs (joint pain, stiffness, reduced range of motion); early intervention improves outcomes

    Report any persistent joint symptoms to physician; consider imaging if recurrent pain, particularly in knees