rs11741688 - ZNF454 - GRM6

Magnitude 4.5 · 1 study on file

Reported associations

• Novel Loci Associated with Usual Sleep Duration: The CHARGE Consortium Genome-Wide Association Study - Unknown journal (n.d.) · Unknown authors · PubMed 25469926

  ABSTRACT: Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study of usual sleep duration was conducted using 18 population-based cohorts totaling 47,180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35-80 kb upstream from the thyroid-specific transcription factor PAX8 (lowest p=1.1 × 10−9). This finding was replicated in an African-American sample of 4771 individuals (lowest p=9.3 × 10−4). The strongest combined association was at rs1823125 (p=1.5 × 10−10, minor allele frequency 0.26 in the disc

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