Expressive

rs117413713 - NRG1

Magnitude 2.2 · 1 study on file

Reported associations

  • Association of SUMOylation Pathway Genes With Stroke in a Genome-Wide Association Study in India. - Neurology (2021) · Kumar A, Chauhan G, Sharma S, Dabla S, Sylaja PN, Chaudhary N, Gupta S, Agrawal CS, Anand KS, Srivastava AK, Vibha D, Sagar R, Raj R, Maheshwari A, Vivekanandhan S, Kaul B, Raghavan S, Gorthi SP, Mohania D, Kaushik S, Yadav RK, Hazarika A, Sharma P, Prasad K · PubMed 34031191

    To undertake a genome-wide association study (GWAS) to identify genetic variants for stroke in an Indian population. In a hospital-based case-control study, 8 teaching hospitals in India recruited 4,088 participants, including 1,609 stroke cases. Imputed genetic variants were tested for association with stroke subtypes using both single-marker and gene-based tests. Association with vascular risk factors was performed with logistic regression. Various databases were searched for replication, functional annotation, and association with related traits. Status of candidate genes previously reported in the Indian population was also checked. Associations of vascular risk factors with stroke were similar to previous reports and show modifiable risk factors such as hypertension, smoking, and alco

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • lipid and glucose panel Moderate

    Dyslipidemia and hyperglycemia are major risk factors for small vessel stroke

    baseline panel if not recent, repeat as clinically indicated

Diet

  • Mediterranean or DASH diet pattern Moderate

    Heart-healthy dietary patterns reduce cardiovascular disease and stroke risk

    emphasize vegetables, fruits, whole grains, fish, limit sodium

Discuss with your doctor

  • small vessel stroke risk from NRG1 variant Moderate

    rs117413713 confers 1.2-fold increased small vessel stroke risk per GWAS analysis

Exercise

  • regular aerobic exercise Moderate

    Regular aerobic activity improves cardiovascular health and reduces stroke risk

    aim for 150 minutes moderate intensity per week or 75 minutes vigorous

Lifestyle

  • blood pressure Moderate

    Hypertension is a major modifiable risk factor for small vessel stroke

    monitor regularly, target <130/80 mmHg

  • tobacco smoking Moderate

    Smoking significantly increases small vessel stroke risk and should be avoided

Screening

  • cardiovascular risk assessment Moderate

    Genetic predisposition to small vessel stroke warrants evaluation of modifiable cardiovascular risk factors

    discuss screening options with healthcare provider