rs11740768 - UIMC1

Magnitude 2.0 · 1 study on file

Reported associations

• Genetic contribution of reproductive traits to risk of uterine leiomyomata: a large-scale, genome-wide, cross-trait analysis. - American journal of obstetrics and gynecology (2024) · Xiao C, Wu X, Gallagher CS, Rasooly D, Jiang X, Morton CC · PubMed 38191017

  Although phenotypic associations between female reproductive characteristics and uterine leiomyomata have long been observed in epidemiologic investigations, the shared genetic architecture underlying these complex phenotypes remains unclear. We aimed to investigate the shared genetic basis, pleiotropic effects, and potential causal relationships underlying reproductive traits (age at menarche, age at natural menopause, and age at first birth) and uterine leiomyomata. With the use of large-scale, genome-wide association studies conducted among women of European ancestry for age at menarche (n=329,345), age at natural menopause (n=201,323), age at first birth (n=418,758), and uterine leiomyomata (n /n =35,474/267,505), we performed a comprehensive, genome-wide, cross-trait analysis to exami

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