Expressive

rs117386039 - STXBP6 - LINC02286

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association study meta-analysis of suicide death and suicidal behavior - Unknown journal (n.d.) · Unknown authors · PubMed 36253440

    ABSTRACT: Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated with suicide death and suicidal behavior. Meta-analysis for suicide death was performed using 3765 cases from Utah and matching 6572 controls of European ancestry. Meta-analysis for suicidal behavior using data across five cohorts (n = 8315 cases and 256,478 psychiatric or populational controls of European ancestry) was also performed. One locus in neuroligin 1 (NLGN1) passing the genome-wide significance threshold for suicide death was identified (top SNP rs73182688, with p = 5.48 × 10−8 before and p = 4.55 × 10−8 after mtCOJO analysis conditioning on MDD to remove genetic effects on suicide mediated by MDD). Conditioning on suicidal attempts did not significantl

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Psychiatric risk and suicide prevention strategies Moderate

    GWAS association with suicide behavior identifies individuals for preventive discussion

    Discuss genetic finding with psychiatrist or mental health provider

Exercise

  • Regular physical activity for mental health Moderate

    Exercise is evidence-based intervention for mood disorders and suicide prevention

    Aerobic exercise 150 minutes per week or resistance training 2x per week

Lifestyle

  • Maintain strong social connections and support Moderate

    Social isolation is risk factor for suicide; social support is protective factor

    Regular social engagement with close relationships and support network

  • Sleep quality and consistency Moderate

    Sleep disruption is risk factor for mood disorders and suicidal ideation

    Maintain 7-9 hours nightly with consistent sleep schedule

  • Stress management and mindfulness practices Moderate

    Stress is modifiable risk factor for psychiatric outcomes and mood disorders

    Daily mindfulness, meditation or stress management, 10-30 minutes

Screening

  • Mental health status and mood symptoms Moderate

    Genetic variant associated with suicide behavior; baseline assessment guides prevention

    Annual mental health screening or as symptoms develop