rs11737509 - UNC93B7 - OR7E83P
Magnitude 2.2 · 1 study on file
Reported associations
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Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484
ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Serum urate level testing Moderate
rs11737509 A allele increases serum urate; baseline testing enables hyperuricemia detection and gout risk assessment.
Annual or biennial serum urate level test
Discuss with your doctor
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Urate management strategy and gout risk Moderate
Genetic predisposition to elevated urate increases hyperuricemia and gout risk; clinical assessment helps determine personalized management.
Discuss with physician: assess urate-related cardiovascular risk, gout prevention strategies, and monitoring approach