Expressive

rs117370931 - LINGO2 - ME2P1

Magnitude 4.5 · 1 study on file

Reported associations

  • Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas - Unknown journal (n.d.) · Unknown authors · PubMed 38714721

    ABSTRACT: Adverse pregnancy outcomes (APOs) affect a large proportion of pregnancies and represent an important cause of morbidity and mortality worldwide. Yet the pathophysiology of APOs is poorly understood, limiting our ability to prevent and treat these conditions. To search for genetic markers of maternal risk for four APOs, we performed multi-ancestry genome-wide association studies (GWAS) for pregnancy loss, gestational length, gestational diabetes, and preeclampsia. We clustered participants by their genetic ancestry and focused our analyses on three sub-cohorts with the largest sample sizes: European, African, and Admixed American. Association tests were carried out separately for each sub-cohort and then meta-analyzed together. Two novel loci were significantly associated with an

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • low glycemic index foods Moderate

    Low GI diet improves glucose tolerance and reduces gestational diabetes risk

    emphasize whole grains, vegetables, legumes; limit refined carbohydrates

Exercise

  • regular aerobic and resistance exercise Moderate

    Physical activity improves insulin sensitivity and reduces gestational diabetes risk

    150 minutes per week moderate aerobic activity plus resistance training

Screening

  • gestational diabetes screening in early pregnancy Moderate

    G allele increases gestational diabetes risk 2.76-fold

    discuss earlier glucose tolerance testing with OB/GYN during pregnancy planning