rs117358046 - IFT43

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide analysis of emotional lability in adult attention deficit hyperactivity disorder (ADHD). - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (2020) · Gisbert L, Vilar L, Rovira P, Sánchez-Mora C, Pagerols M, Garcia-Martínez I, Richarte V, Corrales M, Casas M, Ramos-Quiroga JA, Soler Artigas M, Ribasés M · PubMed 31085060

  Emotional lability is strongly associated with Attention Deficit Hyperactivity Disorder (ADHD), represents a major source of impairment and predicts poor clinical outcome in ADHD. Given that no specific genes with a role in the co-occurrence of both conditions have been described, we conducted a GWAS of emotional lability in 563 adults with ADHD. Despite not reaching genome-wide significance, the results highlighted genes related with neurotransmission, cognitive function and a wide range of psychiatric disorders that have emotional lability as common clinical feature. By constructing polygenic risk scores on mood instability in the UK Biobank sample and assessing their association with emotional lability in our clinical dataset, we found suggestive evidence of common genetic variation con

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