Expressive

rs11735173 - DOK7

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide Association Analysis Across 16,956 Patients Identifies a Novel Genetic Association Between BMP6, NIPAL1, CNGA1 and Spondylosis. - Spine (2021) · Zhang Y, Grant RA, Shivakumar MK, Zaleski M, Sofoluke N, Slotkin JR, Williams MS, Lee MTM · PubMed 33332786

    A case-control genome-wide association study (GWAS) on spondylosis. Leveraging Geisinger's MyCode initiative's multimodal dataset, we aimed to identify genetic associations with degenerative spine disease. Degenerative spine conditions are a leading cause of global disability; however, the genetic underpinnings of these conditions remain under-investigated. Previous studies using candidate-gene approach suggest a genetic risk for degenerative spine conditions, but large-scale GWASs are lacking. We identified 4434 patients with a diagnosis of spondylosis using ICD diagnosis codes with genotype data available. We identified a population-based control of 12,522 patients who did not have any diagnosis for osteoarthritis. A linear-mix, additive genetic model was employed to perform the genetic

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic predisposition to spondylosis Moderate

    rs11735173-T carriers have increased genetic risk for spinal degeneration; physician discussion enables informed decisions about prevention and screening.

    Discuss genetic findings, personal and family history of spine disease, and whether preventive measures or imaging screening are appropriate

Exercise

  • Core and paraspinal strengthening Moderate

    Strong core muscles reduce mechanical stress on intervertebral discs and may slow progression of degenerative changes in genetically predisposed spines.

    3-4 sessions weekly of core and back strengthening exercises (20-30 minutes per session)

Screening

  • Baseline spine imaging for degenerative changes Moderate

    Early detection of disc degeneration in genetically predisposed individuals enables timely preventive intervention before symptomatic disease develops.

    Discuss with physician whether baseline MRI or X-ray is appropriate based on age, symptoms, and risk factors