rs11733284 - NIPAL1
Magnitude 2.8 · 1 study on file
Reported associations
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GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes - Unknown journal (n.d.) · Unknown authors · PubMed 27899376
ABSTRACT: Objective A genome-wide association study (GWAS) of gout and its subtypes was performed to identify novel gout loci, including those that are subtype-specific. Methods Putative causal association signals from a GWAS of 945 clinically defined gout cases and 1213 controls from Japanese males were replicated with 1396 cases and 1268 controls using a custom chip of 1961 single nucleotide polymorphisms (SNPs). We also first conducted GWASs of gout subtypes. Replication with Caucasian and New Zealand Polynesian samples was done to further validate the loci identified in this study. Results In addition to the five loci we reported previously, further susceptibility loci were identified at a genome-wide significance level (p<5.0×10−8): urate transporter genes (SLC22A12 and SLC17A1) an
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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magnesium-rich foods Low
NIPAL1 is a magnesium transporter in renal distal tubules; magnesium metabolism associates with uric acid handling
Consume magnesium-rich foods daily: nuts, seeds, leafy greens, whole grains
Screening
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serum uric acid testing Moderate
rs11733284 in NIPAL1 is associated with renal urate underexcretion, a primary genetic cause of gout
Baseline serum uric acid test; repeat annually if normal