rs117332585 - LINC02529 - RPL21P69
Magnitude 2.2 · 1 study on file
Reported associations
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Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484
ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Lipoprotein (a) level measurement High
This SNP strongly associates with elevated Lipoprotein (a), a genetically-determined cardiovascular risk factor.
Measure baseline Lp(a); repeat every 2-3 years or per cardiologist recommendation.
Discuss with your doctor
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Lipoprotein (a) management strategies High
Carriers of this SNP have genetically elevated Lp(a); targeted medical interventions may reduce cardiovascular risk.
Review options including high-intensity statin therapy, PCSK9 inhibitors, or Lp(a)-specific therapies.
Exercise
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Regular aerobic exercise Moderate
Physical activity may modestly reduce Lp(a) levels and improve cardiovascular health.
150 minutes per week of moderate-intensity aerobic exercise.