rs117321479 - SOX5

Magnitude 2.2 · 1 study on file

Reported associations

• Meta-analysis of genome-wide association studies of hoarding symptoms in 27,651 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 36379924

  ABSTRACT: Hoarding Disorder (HD) is a mental disorder characterized by persistent difficulties discarding or parting with possessions, often resulting in cluttered living spaces, distress, and impairment. Its etiology is largely unknown, but twin studies suggest that it is moderately heritable. In this study, we pooled phenotypic and genomic data from seven international cohorts (N = 27,651 individuals) and conducted a genome wide association study (GWAS) meta-analysis of parent- or self-reported hoarding symptoms (HS). We followed up the results with gene-based and gene-set analyses, as well as leave-one-out HS polygenic risk score (PRS) analyses. To examine a possible genetic association between hoarding symptoms and other phenotypes we conducted cross-trait PRS analyses. Though we d

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